RX 801077

RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI) [1][2].

Product Specifications

CAS Number

[72583-92-7]

Product Name Alternative

2 BFI (free base)

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Imidazoline Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rx-801077.html

Solubility

10 mM in DMSO

Smiles

C1(C2=CC3=CC=CC=C3O2)=NCCN1

Molecular Formula

C11H10N2O

Molecular Weight

186.21

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272 (2) :681-8.|[2]Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.