F1324 (TFA)
F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 TFA exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].
Product Specifications
UNSPSC
12352209
Target
Bcl-2 Family
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/f1324-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C56)=O.O=C(C(F)(F)F)O
Molecular Formula
C83H121N21O20S.xC2HF3O2
Molecular Weight
1765.04 (free acid)
References & Citations
[1]Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482 (2) :310-316.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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