MPGES1-IN-3
MPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM) [1].
Product Specifications
CAS Number
1469976-70-2
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mpges1-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(F)=CC(C(F)(F)F)=C1)C2=C(OCCO3)C3=C(N(C)C(NC4=C(Cl)C=CC=C4F)=N5)C5=C2
Molecular Formula
C24H16ClF5N4O3
Molecular Weight
538.85
References & Citations
[1]Muthukaman N, et al. Discovery of 2- ((2-chloro-6-fluorophenyl) amino) -N- (3-fluoro-5- (trifluoromethyl) phenyl) -1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Bioorg Med Chem Lett. 2016 Dec 15;26 (24) :5977-5984.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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