C-11
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin, displays cytotoxicity for carcinoma cell lines[1].
Product Specifications
CAS Number
[2007965-97-9]
UNSPSC
12352203
Target
ADC Payload; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-11.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(N)C=C2)C[C@H](C)C(O)=O)=O)=CS1)[C@H]([C@@H](C)CC)NC([C@@]3(C)CCCN3C)=O
Molecular Formula
C38H58N6O7S
Molecular Weight
742.97
References & Citations
[1]Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7 (11) :999-1004.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents
Curated Selection
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