PP7
PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM) . PP7 shows antiviral activities against influenza A virus (IAV), including A (H1N1) pdm09 (EC50=1.4 μM), A (H7N9) and A (H9N2) subtypes[1].
Product Specifications
CAS Number
433238-84-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pp7.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(N2C(/C(C(N2)=O)=C/C3=CC=C(OCC)C=C3)=O)C=C1Cl
Molecular Formula
C18H14Cl2N2O3
Molecular Weight
377.22
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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