PrPSc-IN-1
PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity[1].
Product Specifications
CAS Number
[1315475-30-9]
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/prpsc-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(N2C(C(N/N=C/C3=C(C=CC=C4)C4=NC=C3)=N5)=CC=C2)C5=C1
Molecular Formula
C22H17N5O
Molecular Weight
367.40
References & Citations
[1]Zaccagnini L, et al. Identification of novel fluorescent probes preventing PrPSc replication in prion diseases. Eur J Med Chem. 2017 Feb 15;127:859-873.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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