JAK 3i
Product Specifications
UNSPSC Description
JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak-3i.html
Solubility
10 mM in DMSO
Smiles
CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
Molecular Weight
354.34
References & Citations
[1]Geoffrey A Smith, et al. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100849/JAK-3i-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100849/
Clinical Information
No Development Reported
CAS Number
1918238-72-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
