(S) -4C3HPG
(S) -4C3HPG ((S) -4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S) -4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice[1].
Product Specifications
CAS Number
85148-82-9
Product Name Alternative
(S) -4-Carboxy-3-hydroxyphenylglycine
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-4c3hpg.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1
Molecular Formula
C9H9NO5
Molecular Weight
211.17
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]C Thomsen, et al. (S) -4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62 (6) :2492-5.|[2]Thomsen C, et al. (S) -4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62 (6) :2492-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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