(S) -4C3HPG

(S) -4C3HPG ((S) -4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S) -4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice[1].

Product Specifications

CAS Number

[85148-82-9]

Product Name Alternative

(S) -4-Carboxy-3-hydroxyphenylglycine

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-4c3hpg.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1

Molecular Formula

C9H9NO5

Molecular Weight

211.17

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]C Thomsen, et al. (S) -4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62 (6) :2492-5.|[2]Thomsen C, et al. (S) -4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994 Jun;62 (6) :2492-5.