Cis-α- (Carboxycyclopropyl) glycine

Cis-α- (Carboxycyclopropyl) glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α- (Carboxycyclopropyl) glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively) . cis-α- (Carboxycyclopropyl) glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].

Product Specifications

CAS Number

[117857-95-1]

Product Name Alternative

L-CCG III

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cis-α-carboxycyclopropyl-glycine.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]1([C@H](N)C(O)=O)[C@H](C(O)=O)C1

Molecular Formula

C6H9NO4

Molecular Weight

159.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Y Nakamura, et al. (2S,3S,4R) -2- (carboxycyclopropyl) glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology. 1993 Sep;32 (9) :833-7. |[2]Charbel El-Hajj Moussa, et al. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R) -2- (carboxycyclopropyl) glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res. 2002 Feb;27 (1-2) :27-35.