cis-α-(Carboxycyclopropyl)glycine
Product Specifications
UNSPSC Description
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes[1][2].
Target Antigen
EAAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cis-α-carboxycyclopropyl-glycine.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]1([C@H](N)C(O)=O)[C@H](C(O)=O)C1
Molecular Weight
159.14
References & Citations
[1]Y Nakamura, et al. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology. 1993 Sep;32(9):833-7. |[2]Charbel El-Hajj Moussa, et al. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochem Res. 2002 Feb;27(1-2):27-35.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100838/cis-α-Carboxycyclopropyl-glycine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100838/
Clinical Information
No Development Reported
CAS Number
117857-95-1
Curated Selection
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