5,7-Dichlorokynurenic acid (sodium)

5,7-Dichlorokynurenic acid (sodium) is the sodium form of 5,7-Dichlorokynurenic acid (HY-100834) . 5,7-Dichlorokynurenic acid is a selective and competitive antagonist of the glycine site on the NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduces NMDA-induced neuron injury in rat cortical cell cultures[1].

Product Specifications

CAS Number

[1184986-70-6]

Product Name Alternative

5,7-DCKA (sodium)

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-7-dichlorokynurenic-acid-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1)O[Na]

Molecular Formula

C10H4Cl2NNaO3

Molecular Weight

280.04

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120 (1) :17-20.|[2]McNamara D, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120 (1) :17-20.