(S) - (-) -HA 966

(S) - (-) -HA 966 ((-) -HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S) - (-) -HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].

Product Specifications

CAS Number

[111821-58-0]

Product Name Alternative

(-) -HA 966

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-minus-ha-966.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C1N(O)CC[C@@H]1N

Molecular Formula

C4H8N2O2

Molecular Weight

116.12

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]B A Morrow, et al. (S) - (-) -HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. J Pharmacol Exp Ther. 1997 Nov;283 (2) :712-21.|[2]L Singh, et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+) -HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-) -HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A. 1990 Jan;87 (1) :347-51.