2-Hydroxysaclofen

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats[1][2][3].

Product Specifications

CAS Number

[117354-64-0]

UNSPSC

12352005

Hazard Statement

H314

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-hydroxysaclofen.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)

Smiles

O=S(CC(O)(CN)C1=CC=C(Cl)C=C1)(O)=O

Molecular Formula

C9H12ClNO4S

Molecular Weight

265.71

Precautions

H314

References & Citations

[1]Varani AP, et al. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5.|[2]Miranda F, et al. The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure. Pharmacol Biochem Behav. 2009 Jul;93 (1) :25-30.|[3]Akema T, et al. 2-Hydroxysaclofen, a potent GABAB receptor antagonist, stimulates luteinizing hormone secretion in female rats. Brain Res. 1991 Apr 12;546 (1) :143-5.