D-Serine-d3
Product Specifications
UNSPSC Description
D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].
Target Antigen
Endogenous Metabolite; iGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
96.36
Solubility
H2O : 50 mg/mL (ultrasonic;warming)
Smiles
OC([C@@](N)([2H])C([2H])([2H])O)=O
Molecular Weight
108.11
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.|[2]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[3]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25.|[4]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.|[5]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Clinical Information
No Development Reported
CAS Number
1414348-52-9
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