Quinolinic acid-13C7
Quinolinic acid-13C7 is the 13C labeled Quinolinic acid (HY-100807) . Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
Product Specifications
CAS Number
[1346642-91-8]
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite; iGluR; Isotope-Labeled Compounds; NO Synthase; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/quinolinic-acid-13c7.html
Solubility
10 mM in DMSO
Smiles
O[13C]([13C]1=[13C](N=[13CH][13CH]=[13CH]1)[13C](O)=O)=O
Molecular Formula
13C7H5NO4
Molecular Weight
174.07
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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