Guanylyl Imidodiphosphate (trisodium)

Guanylyl Imidodiphosphate (Guanosine 5'-[β, γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3].

Product Specifications

CAS Number

[148892-91-5]

Product Name Alternative

Guanosine 5'-[β, γ-imido]triphosphate (trisodium)

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Adenylate Cyclase

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/guanylyl-imidodiphosphate-trisodium.html

Purity

90.07

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(NP(O)(O)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=C(N3)N)=O)N=C2.[Na].[Na].[Na]

Molecular Formula

C10H17N6Na3O13P3

Molecular Weight

591.16

Precautions

H315, H319, H335

References & Citations

[1]Mitsunori Kawato, et al. Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem. 2008 Jan 4;283 (1) :166-174.|[2]J Goldberg, et al. Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. Cell. 1998 Oct 16;95 (2) :237-48.|[3]C Gaudin, et al. Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest. 1995 Apr;95 (4) :1676-83.