Mcl1-IN-11
Product Specifications
UNSPSC Description
Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl1-in-11.html
Solubility
10 mM in DMSO
Smiles
CC1(C)C2=CC(C)=C(C(C3=CC=C(C(NS(=O)(C4=CC=C(NCCSC5=CC=CC=C5)C([N+]([O-])=O)=C4)=O)=O)C=C3)=C)C=C2C(C)(C)CC1
Molecular Weight
683.88
References & Citations
[1]Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100762/Mcl1-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100762/
Clinical Information
No Development Reported
CAS Number
2042211-13-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
