SS28

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1].

Product Specifications

CAS Number

[141172-08-9]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ss28.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1

Molecular Formula

C18H20O3

Molecular Weight

284.35

References & Citations

[1]Thomas E, et al. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 Oct 17;6:34653.