Pipamperone (dihydrochloride)
Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) . Pipamperone dihydrochloride is also a low-affinity antagonist of D2 receptor (pKi=6.7) . Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].
Product Specifications
CAS Number
2448-68-2
Product Name Alternative
Floropipamide (dihydrochloride) ; McN-JR 3345 (dihydrochloride) ; R 3345 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pipamperone-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N.Cl.Cl
Molecular Formula
C21H32Cl2FN3O2
Molecular Weight
448.40
Precautions
P264-P270-P330-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor
Frequently Asked Questions
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