DDR-TRK-1

DDR-TRK-1, a chemical probe, is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC50 value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

Product Specifications

CAS Number

[1934246-19-1]

UNSPSC

12352005

Target

Discoidin Domain Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DDR1-IN-3.html

Purity

98.90

Solubility

DMSO : 40 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C(C=C3)=CC4=C3[C@@H](C)CN(C4)C5=CN=CN=C5

Molecular Formula

C26H23F3N6O

Molecular Weight

492.50

References & Citations

[1]Zhen Wang, et al. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016 Jun 23; 59 (12) : 5911–5916.