T-3256336
T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity[1].
Product Specifications
CAS Number
[1266227-69-3]
UNSPSC
12352005
Target
IAP
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-3256336.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C([C@H](C2CCC(F)(F)CC2)NC([C@@H](NC)C)=O)=O)C[C@](C[C@@H](OCC)C3)([H])N3C1)N[C@@H]4CCOC5=CC=CC=C45
Molecular Formula
C31H45F2N5O5
Molecular Weight
605.72
References & Citations
[1]Hashimoto K, et al. Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic. J Med Chem. 2013 Feb 14;56 (3) :1228-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CIAP-1; XIAP
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