Y-33075 (hydrochloride)
Y-33075 hydrochloride (Y-39983) is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
Product Specifications
CAS Number
471843-75-1
Product Name Alternative
Y-39983
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/y-33075-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.Cl
Molecular Formula
C16H17ClN4O
Molecular Weight
316.79
References & Citations
[1]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36 (10) :964-70. |[2]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55 (4) :411-7. Epub 2011 Jun 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FA175389-01 2.5 mg
AquaSpark® 515 Singlet Oxygen Probe, Ramot at Tel-Aviv University Ltd. Patent family WO 2017/130191
Sign In for Pricing
View Details FA175389-02 5 mg
AquaSpark® 515 Singlet Oxygen Probe, Ramot at Tel-Aviv University Ltd. Patent family WO 2017/130191
Sign In for Pricing
View Details FA175389-03 10 mg
AquaSpark® 515 Singlet Oxygen Probe, Ramot at Tel-Aviv University Ltd. Patent family WO 2017/130191
Sign In for Pricing
View Details FA175389-04 25 mg
AquaSpark® 515 Singlet Oxygen Probe, Ramot at Tel-Aviv University Ltd. Patent family WO 2017/130191
Sign In for Pricing
View Details 
MBS6377904-01 0.1 mL
FABP5 (Fatty Acid-binding Protein, Epidermal, Epidermal-type Fatty Acid-binding Protein, E-FABP, Fatty Acid-binding Protein 5, Psoriasis-associated Fatty Acid-binding Protein Homolog, PA-FABP) (MaxLight 405)
Sign In for Pricing
View Details MBS6377904-02 5x 0.1 mL
FABP5 (Fatty Acid-binding Protein, Epidermal, Epidermal-type Fatty Acid-binding Protein, E-FABP, Fatty Acid-binding Protein 5, Psoriasis-associated Fatty Acid-binding Protein Homolog, PA-FABP) (MaxLight 405)
Sign In for Pricing
View Details