Olinone
Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].
Product Specifications
CAS Number
[1770789-37-1]
UNSPSC
12352005
Hazard Statement
H301
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/olinone.html
Solubility
10 mM in DMSO
Smiles
CC(NCCCCN1C(CCN2)=C(C2=O)C3=C1C=CC=C3)=O
Molecular Formula
C17H21N3O2
Molecular Weight
299.37
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Rodríguez Y, et al. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins. 2020 Mar;88 (3) :414-430. |[2]Gacias M, et al. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21 (7) :841-854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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