Olinone
Product Specifications
UNSPSC Description
Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/olinone.html
Solubility
10 mM in DMSO
Smiles
CC(NCCCCN1C(CCN2)=C(C2=O)C3=C1C=CC=C3)=O
Molecular Weight
299.37
References & Citations
[1]Rodríguez Y, et al. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins. 2020 Mar;88(3):414-430. |[2]Gacias M, et al. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100670/Olinone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100670/
Clinical Information
No Development Reported
CAS Number
1770789-37-1
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