Didesethyl chloroquine-d4

Didesethyl chloroquine-d4 is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

Product Specifications

CAS Number

[1215797-41-3]

Product Name Alternative

Bisdesethylchloroquine-d4

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

NC([2H])([2H])C([2H])([2H])CC(C)NC1=CC=NC2=C1C=CC(Cl)=C2

Molecular Formula

C14H14D4ClN3

Molecular Weight

267.79

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Biot C, et al. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg Med Chem. 1999 Dec;7 (12) :2843-7.|[3]Essien EE, et al. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J Pharm Pharmacol. 1986 Jul;38 (7) :543-6.