Didesethyl chloroquine-d4
Product Specifications
UNSPSC Description
Didesethyl chloroquine-d4 is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].
Target Antigen
Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
NC([2H])([2H])C([2H])([2H])CC(C)NC1=CC=NC2=C1C=CC(Cl)=C2
Molecular Weight
267.79
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Biot C, et al. Synthesis and antimalarial activity in vitro of potential metabolites of ferrochloroquine and related compounds. Bioorg Med Chem. 1999 Dec;7(12):2843-7.|[3]Essien EE, et al. Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria. J Pharm Pharmacol. 1986 Jul;38(7):543-6.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1215797-41-3
Curated Selection
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