(E) -10-Hydroxynortriptyline (maleate)

(E) -10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

Product Specifications

CAS Number

[74853-74-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-10-hydroxy-nortriptyline-maleate.html

Solubility

10 mM in DMSO

Smiles

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC.O=C(O)/C=C\C(O)=O

Molecular Formula

C23H25NO5

Molecular Weight

395.46

Precautions

P264-P270-P330-P501

References & Citations

[1]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22 (4) :371-8.|[2]Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.