RPR132595A
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine[1].
Product Specifications
CAS Number
[185304-42-1]
Product Name Alternative
NPC
UNSPSC
12352005
Hazard Statement
H301
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rpr132595a.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(N)CC1)OC2=CC=C3N=C4C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C54)=O)=C(CC)C3=C2
Molecular Formula
C28H30N4O6
Molecular Weight
518.56
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan.Anal Chem. 2018 May 15;90 (10) :6012-6019.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
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