Ro 20-0657/000
Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine[1][2][3].
Product Specifications
CAS Number
29606-06-2
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ro-20-0657-000.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N)N=C2N
Molecular Formula
C14H18N4O4
Molecular Weight
306.32
Precautions
P264-P270-P330-P501
References & Citations
[1]Robert E. London, et al. Nuclear magnetic resonance study of interaction of ligands with Streptococcus faecium dihydrofolate reductase labeled with [.gamma.-13C]tryptophan. Biochemistry 1982, 21, 18, 4450-4458.|[2]van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579 (2) :354-60.|[3]Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411 (20) :5209-5222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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