Ro 20-0657/000

Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine[1][2][3].

Product Specifications

CAS Number

[29606-06-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ro-20-0657-000.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N)N=C2N

Molecular Formula

C14H18N4O4

Molecular Weight

306.32

Precautions

P264-P270-P330-P501

References & Citations

[1]Robert E. London, et al. Nuclear magnetic resonance study of interaction of ligands with Streptococcus faecium dihydrofolate reductase labeled with [.gamma.-13C]tryptophan. Biochemistry 1982, 21, 18, 4450-4458.|[2]van 't Klooster GA, et al. Determination of trimethoprim and its oxidative metabolites in cell culture media and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 1992 Sep 2;579 (2) :354-60.|[3]Tadić Đ, et al. Simultaneous determination of multiclass antibiotics and their metabolites in four types of field-grown vegetables. Anal Bioanal Chem. 2019 Aug;411 (20) :5209-5222.