Cis-ACBD
Cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].
Product Specifications
CAS Number
73550-55-7
Product Name Alternative
Cis-1-Aminocyclobutane-1,3-dicarboxylic acid
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cis-acbd.html
Purity
98.0
Solubility
H2O : 62.5 mg/mL (ultrasonic)
Smiles
OC([C@]1(C[C@@H](C1)C(O)=O)N)=O
Molecular Formula
C6H9NO4
Molecular Weight
159.14
Precautions
H315, H319, H335
References & Citations
[1]Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71 (4) :192-8.|[2]Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47 (2) :267-74.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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