Cis-ACBD

Cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

Product Specifications

CAS Number

[73550-55-7]

Product Name Alternative

Cis-1-Aminocyclobutane-1,3-dicarboxylic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cis-acbd.html

Purity

98.0

Solubility

H2O : 62.5 mg/mL (ultrasonic)

Smiles

OC([C@]1(C[C@@H](C1)C(O)=O)N)=O

Molecular Formula

C6H9NO4

Molecular Weight

159.14

Precautions

H315, H319, H335

References & Citations

[1]Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71 (4) :192-8.|[2]Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47 (2) :267-74.