SGC2085 (hydrochloride)

SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins[1].

Product Specifications

CAS Number

[1821908-49-9]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sgc2085-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.CC1=CC(OC2=CC=C(CNC([C@@H](N)C)=O)C=C2C)=CC(C)=C1

Molecular Formula

C19H25ClN2O2

Molecular Weight

348.87

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT6

Curated Selection

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