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Zenidolol

Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research[1].

Product Specifications

CAS Number

[72795-26-7]

Product Name Alternative

ICI-118551

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zenidolol.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@H](NC(C)C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2

Molecular Formula

C17H27NO2

Molecular Weight

277.40

Precautions

H315, H319, H335

References & Citations

[1]Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369 (2) :151-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Adv Sci (Weinh) . 2025 Oct 6:e04817.|bioRxiv. 2024 Feb 19.|J Endocrinol. 2023 Feb 16;256 (3) :e220335.|Nat Commun. 2023 May 2;14 (1) :2523.|Adv Sci (Weinh) . 2024 Sep 4:e2402393.|Biochem Biophys Res Commun. 2024 Apr 9:703:149689.|Biomed Pharmacother. 2023 May:161:114523.|bioRxiv. 2020 Jan.|bioRxiv. 2025 Jul 26:2025.07.22.666009.|BMC Ophthalmol. 2021 Dec 5;21 (1) :419.|BMC Cancer. 2019 Nov 26;19 (1) :1142.|Br J Pharmacol. 2020 Jan;177 (2) :282-297. |Cancer Discov. 2025 Jan 13;15 (1) :202-226.|Cell Rep. 2025 Sep 23;44 (10) :116337.|Commun Biol. 2021 Dec 3;4 (1) :1359.|Commun Biol. 2022 Apr 8;5 (1) :339.|Diabetes. 2022 May 1;71 (5) :921-933.|Environ Toxicol. 2024 Mar;39 (3) :1682-1699.|Eur J Pharmacol. 2022 Aug 5:928:175110.|Int Dent J. 2024 Jul 22:S0020-6539 (24) 00166-7.|Int J Biol Sci. 2023 Apr 2;19 (7) :2006-2019.|Int J Nanomedicine. 2025 May 12:20:6023-6041.|Invest Ophthalmol Vis Sci. 2025 Jun 2;66 (6) :13.|J Exp Clin Cancer Res. 2019 Apr 25;38 (1) :174. |J Exp Med. 2023 Nov 6;220 (11) :e20230577.|J Nutr Biochem. 2018 Aug:58:110-118.|J Oral Maxillofac Surg. 2020 Oct;78 (10) :1871.e1-1871.e23.|J Pharm Anal. 2024 Jul;14 (7) :100934.|Mol Oncol. 2022 Aug;16 (15) :2881-2895.|Nat Commun. 2020 Sep 25;11 (1) :4857.|Nat Commun. 2021 Nov 26;12 (1) :6937.|Nat Commun. 2024 Nov 28;15 (1) :10361.|Neuroscience. 2019 Mar 1:401:59-72.|Oncol Rep. 2016 Sep;36 (3) :1576-84. |Pflugers Arch. 2021 Dec;473 (12) :1899-1910.|Research Square Preprint. 2020 Oct.|Research Square Preprint. 2021 Feb.|Research Square Preprint. 2021 Nov.|Research Square Preprint. 2021 Sep.|Research Square Preprint. 2022 Mar.|Sci Adv. 2024 Jul 19;10 (29) :eadp5239.

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