(Rac) -Golgicide A
(Rac) -Golgicide A ((Rac) -GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1[1].Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species[2].
Product Specifications
CAS Number
[1005036-73-6]
Product Name Alternative
(Rac) -GCA
UNSPSC
12352005
Hazard Statement
H319
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rac-golgicide-a.html
Solubility
10 mM in DMSO
Smiles
FC1=CC2=C(NC(C3C2C=CC3)C4=CN=CC=C4)C(F)=C1
Molecular Formula
C17H14F2N2
Molecular Weight
284.30
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5 (3) :157-65.|[2]van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84 (15) :7535-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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