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Rp-cAMPS

Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

Product Specifications

CAS Number

73208-40-9

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rp-camps.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3

Molecular Formula

C10H12N5O5PS

Molecular Weight

345.27

References & Citations

[1] Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'- (cyclic) phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251 (3) :757-62.|[2]Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26.|[3]Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36 (3) :730-6.|[4]Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265 (18) :10484-91.|[5]Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259 (16) :10020-4.|[6]R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142 (2) :255-60.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Theranostics. 2021 Mar 24;11 (12) :5650-5674.|Cell Commun Signal. 2024 Jun 3;22 (1) :307.|Nat Commun. 2025 Jul 1;16 (1) :5425.|Research Square Preprint. 2024 Apr 9.

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