GR203040
GR203040 is an orally active NK1 receptor antagonist with a pKi of 10.3. GR203040 shows potent antiemetic activity[1].
Product Specifications
CAS Number
168398-02-5
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr203040.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(N2N=NN=C2)C=C1CN[C@@H]3[C@H](C4=CC=CC=C4)NCCC3.[H]Cl.[H]Cl
Molecular Formula
C20H26Cl2N6O
Molecular Weight
437.37
References & Citations
[1]Ward P, et al. Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S) - (2-methoxy-5-tetrazol-1-ylbenzyl) (2-phenylpiperidin-3-yl) amine (GR203040), with potent antiemetic activity. J Med Chem. 1995 Dec 22;38 (26) :4985-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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