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CP 122721 (hydrochloride)

CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects[1][2].

Product Specifications

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-122721-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C(C=C1)OC(F)(F)F)CN[C@H]2CCCN[C@H]2C3=CC=CC=C3.Cl.Cl

Molecular Formula

C20H25Cl2F3N2O2

Molecular Weight

453.33

References & Citations

[1]McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277 (2) :900-8.|[2]Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37 (5) :559-78.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-10049A/CP-122721-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10049A/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NK1R

CAS Number

[145877-52-7]

Available Sizes

Curated Selection

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