LXRβ agonist-2

LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].

Product Specifications

CAS Number

[1949801-52-8]

UNSPSC

12352005

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lxr-beta-agonist-2.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)(C(F)(F)F)C1=CC(CCC)=C(OC2=CC(O)=C(C(CN3C(N[C@@](C)(C4=NC=C(OC(C)C)C=C4)C3=O)=O)=O)C=C2)C=C1

Molecular Formula

C32H31F6N3O7

Molecular Weight

683.59

References & Citations

[1]Koura M, et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24 (16) :3436-46.