NTU281
Product Specifications
UNSPSC Description
NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes[1][2].
Target Antigen
Apoptosis; Glutaminase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ntu281.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(N[C@@H](CCC(C[S+](C)C)=O)C(O)=O)=O)CC1=CC=CC=C1)OCC2=CC=CC=C2
Molecular Weight
487.59
References & Citations
[1]Hornigold N, et al. Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy. Lab Invest. 2013 May;93(5):553-65.|[2]Huang L, et al. Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy? Nephrol Dial Transplant. 2010 Dec;25(12):3897-910.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100446/NTU281-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100446/
Clinical Information
No Development Reported
CAS Number
815619-12-6
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