Osemozotan (hydrochloride)
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].
Product Specifications
CAS Number
137275-80-0
Product Name Alternative
MKC242
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/osemozotan-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.[C@@H]1(CNCCCOC2=CC=C(OCO3)C3=C2)OC4=CC=CC=C4OC1
Molecular Formula
C19H22ClNO5
Molecular Weight
379.83
References & Citations
[1]Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174 (4) :314-327.|[2]Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32 (4) :728-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor
Available Sizes
Frequently Asked Questions
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