MS049 (dihydrochloride)
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells[1].
Product Specifications
CAS Number
2095432-59-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms049-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
CNCCN1CCC(OCC2=CC=CC=C2)CC1.[H]Cl.[H]Cl
Molecular Formula
C15H26Cl2N2O
Molecular Weight
321.29
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT4; PRMT6
Frequently Asked Questions
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