MS049 (dihydrochloride)

MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells[1].

Product Specifications

CAS Number

[2095432-59-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms049-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

CNCCN1CCC(OCC2=CC=CC=C2)CC1.[H]Cl.[H]Cl

Molecular Formula

C15H26Cl2N2O

Molecular Weight

321.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Oct 13;59 (19) :9124-9139.