(Rac) -Nutlin-3
(Rac) -Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM) . (Rac) -Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. (Rac) -Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].
Product Specifications
CAS Number
890090-75-2
Product Name Alternative
(Rac) -Rebemadlin
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rac-nutlin-3.html
Purity
98.18
Solubility
10 mM in DMSO
Smiles
O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=NC(C3=CC=C(C=C3)Cl)C1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
Precautions
P264-P270-P330-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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