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CBP/p300-IN-5

P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM[1].

Product Specifications

CAS Number

1889284-33-6

UNSPSC

12352005

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p300-cbp-in-5.html

Purity

97.0

Solubility

DMSO : 60 mg/mL (ultrasonic; warming)

Smiles

O=C(CN(C1=O)C(N[C@@]21C[C@H](C3=C2C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)=O)N([C@H](C(F)(F)F)C)CC5=CC=C(C=C5)F

Molecular Formula

C29H27F5N6O4

Molecular Weight

618.55

References & Citations

[1]Michael Michaelides, et al. Spirocyclic hat inhibitors and methods for their use. WO2016044770A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CBP/p300

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