CBP/p300-IN-5
P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM[1].
Product Specifications
CAS Number
1889284-33-6
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p300-cbp-in-5.html
Purity
97.0
Solubility
DMSO : 60 mg/mL (ultrasonic; warming)
Smiles
O=C(CN(C1=O)C(N[C@@]21C[C@H](C3=C2C=CC(C4=CN(N=C4)CC(NC)=O)=C3)F)=O)N([C@H](C(F)(F)F)C)CC5=CC=C(C=C5)F
Molecular Formula
C29H27F5N6O4
Molecular Weight
618.55
References & Citations
[1]Michael Michaelides, et al. Spirocyclic hat inhibitors and methods for their use. WO2016044770A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
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