LY3177833 (monhydrate)
LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 monhydrate is a senescence inducer[1][2].
Product Specifications
CAS Number
1627696-53-0
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ly3177833-monhydrate.html
Purity
99.76
Solubility
10 mM in DMSO
Smiles
O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3.[H]O[H]
Molecular Formula
C16H14FN5O2
Molecular Weight
327.31
References & Citations
[1]Robert Dean Dally, et al. CDC7 Inhibitors. Patent WO2014143601A1.|[2]Li X, et al. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chem Sci. 2020 Jun 17;11 (28) :7292-7301.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDC
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB1960-500 1x 500 µL
GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/1960), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
