MRT68921 (hydrochloride)
Product Specifications
UNSPSC Description
MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.
Target Antigen
ULK
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrt68921-hydrochloride-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl
Molecular Formula
C21H17D3FN3O6S
Molecular Weight
471.04
References & Citations
[1]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.
Shipping Conditions
Room temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100006B/MRT68921-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100006B/
Clinical Information
No Development Reported
CAS Number
2070014-87-6
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