MALT1 Antibody
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT-1) is found in extranodal low-grade B cell lymphomas. The gene encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT-1 gene and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18) (q21; q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT-1 caspase-like domain. MALT-1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Product Specifications
UniProt
Q9UDY8
Reactivity
Human
Immunogen
Amino acids 701-808 from the human protein were used as the immunogen for this MALT1 antibody.
Clonality
Monoclonal
Clone
SPM578
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa
Available Sizes
Frequently Asked Questions
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