Beclin1-ATG14L interaction inhibitor 1
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1].
Product Specifications
CAS Number
[1243063-73-1]
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/beclin1-atg14l-interaction-inhibitor-1.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=NOC(C3CCC3)=N2)C4=CC(S(=O)(NC5=CC=CC(C)=C5C)=O)=CC=C4OC1
Molecular Formula
C23H24N4O5S
Molecular Weight
468.53
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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