Poloxamer 407 (F127)

Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8 AM and Quest Rhod-4 AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor[1][2].

Product Specifications

CAS Number

[9003-11-6]

Product Name Alternative

PEG-PPG-PEG, 12600 (Average Mn)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

LPL Receptor

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/poloxamer-407.html

Solubility

H2O : 110 mg/mL (ultrasonic)

Smiles

CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]

Molecular Weight

12600 (Average)

Precautions

H302, H315, H319, H335

References & Citations

[1]Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87 (1) :42-8.|[2]Peng X, et al. Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr-/- Mice. Cells. 2022 May 30;11 (11) :1795.