VEGFR2 Antibody / VEGF Receptor 2 / KDR
This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.
Product Specifications
UniProt
P35918
Reactivity
Mouse
Immunogen
Recombinant full-length Mouse VEGFR2 protein was used as the immunogen for this VEGFR2 antibody.
Clonality
Monoclonal
Clone
DC101
Conjugation
Unconjugated
Field of Research
Cardiovascular Research; Cell Biology
Purification
Protein G affinity chromatography
Dilution
Western blot (Non-reducing) : 2-5ug/ml, Blocks binding of VEGF to VEGF-R2, Inhibits VEGF-induced signalingformat), Blocks tumor growth in mice
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the VEGFR2 antibody should be determined by the researcher.
Tested Applications
Blocking, NeA, WB
Host or Source
Rat
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Rat IgG1, kappa
Available Sizes
Frequently Asked Questions
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