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Bromo-PEG1-C2-azide

Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1144106-65-9]

UNSPSC

12352211

Hazard Statement

H242, H301, H372

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bromo-peg1-c2-azide.html

Purity

99.45

Solubility

DMSO : ≥ 350 mg/mL

Smiles

BrCCOCCN=[N+]=[N-]

Molecular Formula

C4H8BrN3O

Molecular Weight

194.03

Precautions

H242, H301, H372

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Curated Selection

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